Inclusion Complexes of Promethazine with Monochlorotriazinyl-β-cyclodextrin

Formation of inclusion complexes of monochlorotriazinyl-β-cyclodextrin with promethazine was studied, for establishing the optimal conditions of their formation, in view of subsequent grafting on cellulose textiles with potential medicinal use. The infrared spectral study of inclusion in solid state indicated that the complex can be even formed by physically mixing the two substances. By the co-precipitation method, one can obtain a complex with obvious spectral changes, compared to the spectra of the two substances viewed separately. The stability constants of the complex in aqueous medium, in both acid and alkaline environment, were established by means of UV spectra and BenesiHildebrand equation. The value of the stability constant obtained is ten times higher in acid than in alkaline medium, which indicates that the alkaline medium is more favourable for producing the complex.